Nitric Acid → HCID 14405001, compound
Reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11].[N+:12]([O-])([OH:14])=[O:13]>C(O)(=O)C.ClCCl>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([N+:12]([O-:14])=[O:13])[C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
20 g of 2,6-dichloro-3,5-difluorophenol are initially introduced in 70 ml of acetic acid, and 8 g of 98% strength nitric acid are added dropwise. Stirring is subsequently continued at room temperature for 2 hours, and the mixture is taken up in 150 ml of dichloromethane and washed twice with water. After the dichloromethane has been distilled off, 18 g of product remain. Purity 94% according to GC analysis.
Workup
- washwashed twice with water
- distillationAfter the dichloromethane has been distilled off
Sources & evidence
- ORD record
- ord-8a10768ac2cf409bbb96233cc6b7a57e
- Source dataset
- uspto-grants-1992_11
- Patent number
- US05166392
Reaction notes
Loading…