D-(-)-Fructose → 3-Hydroxybutyrate 4-hydroxybutyrate

HRID 374384

Reaction equation

OCC([C@H:5]([C@@H:7]([C@@H:9]([CH2:11][OH:12])O)[OH:8])O)=O.[OH:13][CH2:14][CH2:15][CH2:16][C:17]([O-:19])=[O:18].[Na+]>>[OH:8][CH:7]([CH3:5])[CH2:9][C:11]([O-:12])=[O:13].[OH:13][CH2:14][CH2:15][CH2:16][C:17]([O-:19])=[O:18]

Participants

Reactant 2

HCID 5984D-(-)-Fructose

HCID 23663870Sodium Oxybate

Product 1

HCID 867491833-Hydroxybutyrate 4-hydroxybutyrateYield 20%

Procedure

The procedure of Example 2 was repeated except that the fructose was replaced with sodium 4-hydroxybutyrate (manufactured by Aldrich Corporation) to produce 1.2 g of 3-hydroxybutyrate-4-hydroxybutyrate copolymer (comprising 20% by mole of 4-hydroxybutyrate unit) having a number average molecular weight of 467,000. The thus produced copolymer product was added to a 100 ml solution comprising 1 volume of aqueous solution of sodium hypochroride (manufactured by Wako Pharmaceutical K.K.) and 1 volume of distilled water, and the suspension was heated to 50° C. for 2 hours. The resulting product had a number average molecular weight of 182,000.

Sources & evidence

ORD record: ord-8a5039f60afa42afa6418534e0bb4e31
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05480394

Linked notes

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