Thionyl Chloride → HCID 13597868, compound

HRID 374422

Reaction equation

HRID 374422 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([OH:10])=O.S(Cl)([Cl:13])=O>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([Cl:13])=[O:10]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 8179723-Bromoisonicotinic acid

Product 1

HCID 13597868HCID 13597868, compound

Procedure

3-Bromopyridine-4-carboxylic acid (5.0 g) was dissolved in thionyl chloride (50 ml) and the solution heated under reflux for 4 hours, cooled and evaporated in vacuo. Re-evaporation of added toluene gave 3-bromopyridine4-carbonyl chloride, m.p.151°-154° C. (dec.) (5.45 g) as a green solid.

Workup

  1. temperaturethe solution heated
  2. temperatureunder reflux for 4 hours
  3. temperaturecooled
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-f8192f4fac954ba7bd348f63b541c8bf
Source dataset
uspto-grants-1996_01
Patent number
US05480857

Linked notes

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