1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone → HCID 86748134, compound

Reaction equation

[CH3:1][N:2]1[CH:8]2[CH2:9][CH2:10][CH:3]1[CH:4](C(=O)C)[CH2:5][CH2:6][CH2:7]2.[C:14](C1C2NC(CCC=1)CC2)(=[O:16])C.C[N:27]1C2CCC1C(C(=O)C)CC2>>[CH3:14][O:16][N:27]=[C:7]1[CH2:6][CH2:5][CH2:4][CH:10]2[CH2:9][CH:8]1[N:2]([CH3:1])[CH2:3]2

Participants

Reactant 3

HCID 4317341-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone

HCID 18966537HCID 18966537, compound

HCID 18995706HCID 18995706, compound

Product 1

HCID 86748134HCID 86748134, compound

Procedure

Similarly when N-methyl-2-acetyl-9-azabicyclo [4.2.1]nonane, which can be prepared from 2-acetyl-9-azabicyclo [4.2.1]non-2-ene which is commercially available, is substituted for N-methyl-2-acetyl-8-azabicyclo [3.2.1]octane, compound (5) , N-methyl-8-azabicyclo [4.2.1 ]nonan-2-one methyl oxime is obtained.

Sources & evidence

ORD record: ord-404a711e206f4745b9e127983f468b90
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482938

Reaction notes

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