5,6-Diamino-1,3-diethyluracil → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,3-dimethyl-4-methoxy)phenyl)ethenyl)-, (E)-

HRID 375295

Reaction equation

HRID 375295 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][O:16][C:17]1[CH:27]=[CH:26][C:20]([CH:21]=[CH:22][C:23](O)=O)=[C:19]([CH3:28])[C:18]=1[CH3:29]>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:23](/[CH:22]=[CH:21]/[C:20]3[CH:26]=[CH:27][C:17]([O:16][CH3:15])=[C:18]([CH3:29])[C:19]=3[CH3:28])=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 45721335,6-Diamino-1,3-diethyluracilHCID 534017704-Methoxy-2,3-dimethylcinnamic acid

Product 1

HCID 64488571H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,3-dimethyl-4-methoxy)phenyl)ethenyl)-, (E)-

Procedure

Substantially the same procedure as in Example 7 was repeated using 2.5 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 2.9 g (13.9 mmol) of 4-methoxy-2,3-dimethylcinnamic acid. Then, the resultant crude crystals were recrystallized from ethanol/water to give 0.80 g (yield of Compound 72 as white crystals.

Workup

  1. customThen, the resultant crude crystals were recrystallized from ethanol/water

Sources & evidence

ORD record
ord-87dc8dc2faf64499a136372f41208257
Source dataset
uspto-grants-1996_01
Patent number
US05484920

Linked notes

Loading…