HCID 19935831, compound → HCID 19935865, compound
Reaction equation
[SH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]2.Cl.[F:15][CH:16]([F:33])[CH2:17][N:18]1[CH2:22][CH2:21][C:20]([C:25]2[CH:30]=[C:29](F)[CH:28]=[C:27]([F:32])[CH:26]=2)([O:23][CH3:24])[CH2:19]1>>[F:32][C:27]1[CH:28]=[C:29]([S:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[N:8]([CH3:12])[C:7](=[O:13])[CH2:6][CH2:5]3)[CH:30]=[C:25]([C:20]2([O:23][CH3:24])[CH2:21][CH2:22][N:18]([CH2:17][CH:16]([F:15])[F:33])[CH2:19]2)[CH:26]=1Participants
3
Procedure
Using an analogous procedure to that described in Example 6, 6-mercapto-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with 1-(2,2-difluoroethyl)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine hydrochloride to give 3-[5-fluoro-3-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-1-(2,2-difluoroethyl)-3-methoxypyrrolidine as a gum in 51% yield.
Sources & evidence
- ORD record
- ord-19ed25f2243a450da9ba031dd1f5acc3
- Source dataset
- uspto-grants-1995_05
- DOI