Thionyl Chloride → 3-(3-Fluorophenyl)propanoyl chloride

HRID 375597

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[CH2:5][CH2:6][C:7](O)=[O:8].S(Cl)([Cl:15])=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[CH2:5][CH2:6][C:7]([Cl:15])=[O:8]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 27374893-(3-Fluorophenyl)propionic acid

Product 1

HCID 189935013-(3-Fluorophenyl)propanoyl chloride

Procedure

A solution of 3-fluorohydrocinnamic acid (28 g) in thionyl chloride (90 ml) was heated at reflux for 3 hours. 3-Fluorohydrocinnamoyl chloride (27 g) was isolated by distillation (150°-110° C. @ ca 20 mm.Hg).

Workup

temperatureat reflux for 3 hours

Sources & evidence

ORD record: ord-66e7a4465c454ece8d230e1ae0a91cbd
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05486541

Linked notes

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