Phenyl isocyanate → 1-Phenyl-4-cyano-5-(phenylureido)-pyrazole

Participants

Role	Name	HCID	Charge
Reactant	Phenyl isocyanate	HCID 7672	—
Reactant	5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile	HCID 79256	—
Reactant	Potassium tert-butoxide	HCID 23665647	—
Solvent	Toluene	HCID 1140	—
Product	1-Phenyl-4-cyano-5-(phenylureido)-pyrazole	HCID 18993713	96%

Reaction Conditions

Temperature	80 °C

Reaction Steps

9.0 g (80 mmol) of potassium tert-butylate and 8.7 ml (80 mmol) of phenyl isocyanate were added to a solution of 5.52 g (30 mmol) of 1-phenyl-4-cyano-5-aminopyrazole in 100 ml of toluene. The mixture was heated for 15 hours at 80° C. and then cooled, the insoluble constituents were separated off and the resulting solution was acidified with acetic acid, the product crystallizing out. Yield: 96%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05486618
Source dataset	uspto-grants-1996_01
ORD ID	ord-d3008fed65aa48ba88f258b2fe528189
Source note	uspto-grants-1996_01