3-Methylglutaric anhydride → 4-[N-{(1RS,2RS)-2-(4-biphenylyl)-1-methyl-3-(2-naphthyl)propyl}carbamoyl]-3-methylbutanoic acid

HRID 376179

Reaction equation

HRID 376179 reaction equation
[C:1]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:6]=[CH:5][C:4]([CH:7]([CH2:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=2)[CH:8]([NH2:10])[CH3:9])=[CH:3][CH:2]=1.[CH3:28][CH:29]1[CH2:35][C:34](=[O:36])[O:33][C:31](=[O:32])[CH2:30]1>>[C:1]1([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:6]=[CH:5][C:4]([CH:7]([CH2:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=2)[CH:8]([NH:10][C:34]([CH2:35][CH:29]([CH3:28])[CH2:30][C:31]([OH:33])=[O:32])=[O:36])[CH3:9])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 778283-Methylglutaric anhydrideHCID 19073559(1RS,2RS)-2-(4-biphenylyl)-1-methyl-3-(2-naphthyl)propylamine

Product 1

HCID 190737764-[N-{(1RS,2RS)-2-(4-biphenylyl)-1-methyl-3-(2-naphthyl)propyl}carbamoyl]-3-methylbutanoic acid

Procedure

Compounds of Examples 57 to 65 were prepared in the same manner as in Example 56 except that (1RS, 2RS)-2-(4-biphenylyl)-1-methyl-3-(2-naphthyl)propylamine and/or 3-methylglutaric anhydride used as the starting materials in the above reaction were changed to the corresponding amine compounds and/or acid anhydrides.

Workup

  1. customused as the starting materials in the above reaction

Sources & evidence

ORD record
ord-f997a304720242e9ad974354c42556cb
Source dataset
uspto-grants-1996_01
Patent number
US05488149

Linked notes

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