Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

Participants

Reaction Steps

Hydrazine hydrate (6.5 ml) was added to a solution of 6-chloro-3-methyl-1-(2-methylpropyl)pyrimidine-2,4[1H,3H]-dione (10.0 g) in ethanol (40 ml). The mixture was heated at reflux for 5 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was recrystallised from ethanol to give the subtitle compound (8.8 g).

Provenance & Evidence