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1-(3,5-Dimethylphenyl)piperazine → 1-[(2-Methoxy-6-methyl-5-propylpyridin-3-yl)aminocarbonyl]-4-(3,5-dimethylphenyl)piperazine

HRID 377826
Notes
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Reaction equation

HRID 377826 reaction equation
[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10](=[O:18])OC2C=CC=CC=2)=[CH:7][C:6]([CH2:19][CH2:20][CH3:21])=[C:5]([CH3:22])[N:4]=1.[CH3:23][C:24]1[CH:25]=[C:26]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:27]=[C:28]([CH3:30])[CH:29]=1>>[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10]([N:34]2[CH2:35][CH2:36][N:31]([C:26]3[CH:27]=[C:28]([CH3:30])[CH:29]=[C:24]([CH3:23])[CH:25]=3)[CH2:32][CH2:33]2)=[O:18])=[CH:7][C:6]([CH2:19][CH2:20][CH3:21])=[C:5]([CH3:22])[N:4]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

3

Reactant 2

HCID 27586261-(3,5-Dimethylphenyl)piperazineHCID 19357057Phenyl N-(2-methoxy-6-methyl-5-propylpyridin-3-yl)carbamate

Product 1

HCID 193570271-[(2-Methoxy-6-methyl-5-propylpyridin-3-yl)aminocarbonyl]-4-(3,5-dimethylphenyl)piperazineYield 64%

Procedure

Phenyl N-(2-methoxy-6-methyl-5-propylpyridin-3-yl)carbamate and 1-(3,5-dimethylphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-908c00e21bd44bcc963228d141ac85cb
Source dataset
uspto-grants-2000_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06028195

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes