N-[1-(4'-Benzyloxybiphenyl-4-yl)-1-methylethyl]-3-(imidazol-1-yl)propylamine → 4'-{1-[3-(Imidazol-1-yl)propylamino]-1-methylethyl}biphenyl-4-ol

HRID 378608Notes

Reaction equation

HRID 378608 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:24][CH2:25][CH2:26][CH2:27][N:28]3[CH:32]=[CH:31][N:30]=[CH:29]3)([CH3:23])[CH3:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd]>[N:28]1([CH2:27][CH2:26][CH2:25][NH:24][C:21]([C:18]2[CH:19]=[CH:20][C:15]([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)=[CH:16][CH:17]=2)([CH3:23])[CH3:22])[CH:32]=[CH:31][N:30]=[CH:29]1

Participants

3

Reactant 1

HCID 18349622N-[1-(4'-Benzyloxybiphenyl-4-yl)-1-methylethyl]-3-(imidazol-1-yl)propylamine

Product 1

HCID 183495964'-{1-[3-(Imidazol-1-yl)propylamino]-1-methylethyl}biphenyl-4-ol

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

N-[1-(4'-Benzyloxybiphenyl-4-yl)-1-methylethyl]-3-(imidazol-1-yl)propylamine was hydrogenated, using palladium on charcoal as catalyst, in IMS at atmospheric pressure to give 4'-{1-[3-(imidazol-1-yl)propylamino]-1-methylethyl}biphenyl-4-ol, m.p. 178-180° C.

Sources & evidence

ORD record
ord-0bd90f0e60824a33beb59541845f763b
Source dataset
uspto-grants-2000_02
Patent number
US06031109

Reaction notes

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