Morpholine → 4-(6-Chloropyrimidin-4-yl)morpholine
Reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
45.0 g (302.1 mmol) of 4,6-dichloropyrimidine are initially charged in 450 ml of water. 26.3 g (302.1 mmol) of morpholine are added, and the mixture is stirred at 90° C. for 16 h. The mixture is then cooled to 0° C., and the precipitate formed is filtered off. The precipitate is washed once with 50 ml of water and air-dried.
Workup
- temperatureThe mixture is then cooled to 0° C.
- customthe precipitate formed
- filtrationis filtered off
- washThe precipitate is washed once with 50 ml of water
- customair-dried
Sources & evidence
- ORD record
- ord-d1f9ab0e57eb42c6b0e421bc0e8cbff6
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08524699B2
Reaction notes
Loading…