Morpholine → 4-(6-Chloropyrimidin-4-yl)morpholine

HRID 37891

Reaction equation

HRID 37891 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:7]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 7960704-(6-Chloropyrimidin-4-yl)morpholine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

45.0 g (302.1 mmol) of 4,6-dichloropyrimidine are initially charged in 450 ml of water. 26.3 g (302.1 mmol) of morpholine are added, and the mixture is stirred at 90° C. for 16 h. The mixture is then cooled to 0° C., and the precipitate formed is filtered off. The precipitate is washed once with 50 ml of water and air-dried.

Workup

  1. temperatureThe mixture is then cooled to 0° C.
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. washThe precipitate is washed once with 50 ml of water
  5. customair-dried

Sources & evidence

ORD record
ord-d1f9ab0e57eb42c6b0e421bc0e8cbff6
Source dataset
uspto-grants-2013_09
Patent number
US08524699B2

Linked notes

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