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THF tetrahydrofurane → DMF dimethylformamide

HRID 379002
Notes
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Reaction equation

HRID 379002 reaction equation
C1[CH2:5][O:4]CC1.O1CCCC1.COCCOC.C(COC)OC.[Li+].C[CH:25]([N-:27][CH:28](C)C)C.[CH:31]([N-:34][CH:35](C)C)(C)C.[Li+].[Li]CCCC.C([Li])CCC>C(Cl)Cl.ClCCl.CCOCC.C(OCC)C.CCOC(C)=O.C(OCC)(=O)C>[CH3:25][N:27]([CH:5]=[O:4])[CH3:28].[CH3:31][N:34]([CH3:35])[CH:5]=[O:4]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

8

Reactant 4

HCID 22180045THF tetrahydrofuraneHCID 22508344DME dimethoxyethaneHCID 86757460LDA lithium diisopropylamideHCID 178506870HCID 178506870, compound

Product 1

HCID 17824068DMF dimethylformamide

Reagents, catalysts & solvents 3

HCID 21910879Et2O diethyletherSolvent

Procedure

THF—tetrahydrofuran; DME—dimethoxyethane; EtOAc—ethyl acetate; Et2O—diethylether; RT—room temperature; LDA—lithium diisopropylamide; CH2Cl2—dichloro-methane; tic—thin layer chromatography; BuLi—butyllithium

Workup

  1. customRT—room temperature

Sources & evidence

ORD record
ord-259923fed0f244e6852dbf2247aaf447
Source dataset
uspto-grants-2001_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06297264B1

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes
HCID 21925356
DCM Dichloromethane
Solvent
HCID 23514209EtOAc EtOAcSolvent