2-Bromo-1-(3,5-difluorophenyl)ethanone → 3-Amino-6-chloro-2-(3,5-difluorobenzoyl)-1-(ethoxycarbonyl)indole

HRID 379751

Reaction equation

HRID 379751 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([NH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.Br[CH2:17][C:18]([C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[CH:21]=1)=[O:19]>>[NH2:7][C:6]1[C:5]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:9][CH:8]=2)[N:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:17]=1[C:18](=[O:19])[C:20]1[CH:21]=[C:22]([F:27])[CH:23]=[C:24]([F:26])[CH:25]=1

Participants

3

Reactant 2

HCID 27783312-Bromo-1-(3,5-difluorophenyl)ethanoneHCID 183678884-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile

Product 1

HCID 183677973-Amino-6-chloro-2-(3,5-difluorobenzoyl)-1-(ethoxycarbonyl)indole

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-bromo-3′,5′-difluoroacetophenone (prepared according to the method of S. Kajigaeshi et al., Bull.Chem.Soc.Jpn., 1987, 60, 1159-1160).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-77ee35e25c6041479b334a0bce2b275d
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Linked notes

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