tert-Butanol → ClCF2-CH2-O-CF2CFHBr

HRID 380085

Reaction equation

HRID 380085 reaction equation
[Cl:1][C:2]([CH2:5][OH:6])([F:4])[F:3].C(O)(C)(C)C.[OH-].[K+].[C:14](=[C:17]([Br:19])[F:18])([F:16])[F:15]>O>[Cl:1][C:2]([CH2:5][O:6][C:14]([CH:17]([Br:19])[F:18])([F:16])[F:15])([F:4])[F:3].[C:2](=[CH:5][O:6][C:14]([CH:17]([Br:19])[F:18])([F:16])[F:15])([F:4])[F:3]

Participants

7

Reactant 4

HCID 6386tert-ButanolHCID 117301-Bromo-1,2,2-trifluoroetheneHCID 14797Potassium HydroxideHCID 38641482-Chloro-2,2-difluoroethan-1-ol

Product 2

HCID 21696368ClCF2-CH2-O-CF2CFHBrYield 89%HCID 88022705HCID 88022705, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a 50 ml glass reactor equipped with PTFE valve and magnetic stirring, 2.4 g (0.02 moles) of ClCF2—CH2—OH, 5 ml of tert-butyl alcohol, 1.1 g (0.02 moli) of KOH and 3.5 g of CF2═CFBr (0.022 moles) are fed. The reaction mixture is left under stirring at room temperature for three hours. The organic phase is then diluted with water, separated, washed twice with slightly acid water by HCl and anhydrified. 5 g of a mixture having the following composition: 89% ClCF2—CH2—O—CF2CFHBr and 11% CF2═CH—O—CF2CFHBr are obtained.

Workup

  1. customIn a 50 ml glass reactor equipped with PTFE valve
  2. waitThe reaction mixture is left
  3. customseparated
  4. washwashed twice with slightly acid water by HCl

Sources & evidence

ORD record
ord-1dc9998e4b1d4138a80acbdb9350282f
Source dataset
uspto-grants-2001_10
Patent number
US06300526B1

Linked notes

Loading…