1-Benzyl-4-piperidone → 4-[3-(4-Fluorophenyl)propyl]piperidin-4-ol

HRID 380491

Reaction equation

HRID 380491 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]I)=[CH:4][CH:3]=1.C([N:19]1[CH2:24][CH2:23][C:22](=[O:25])[CH2:21][CH2:20]1)C1C=CC=CC=1>>[OH:25][C:22]1([CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH2:23][CH2:24][NH:19][CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 192201-Benzyl-4-piperidoneHCID 183648401-Fluoro-4-(3-iodopropyl)benzene

Product 1

HCID 183648764-[3-(4-Fluorophenyl)propyl]piperidin-4-ol

Procedure

The title compound was prepared from 3-(4-fluorophenyl propyliodide and 1-benzyl-4-piperidone as described in Example 122.

Sources & evidence

ORD record
ord-a1e785a3f35840a1994c1b40142788bb
Source dataset
uspto-grants-2001_10
Patent number
US06303593B1

Linked notes

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