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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 3812Generated: October 23, 2026

1-Bromo-3-chloropropane → 1-(1-Phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride

https://huagongshe.com/en/reaction/3812

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-chloropropaneHCID 8006—
ReactantPotassium HydroxideHCID 14797—
Reactant1-(1-Phenylethyl)piperazineHCID 2737134—
SolventDimethyl SulfoxideHCID 679—
Product1-(1-Phenylethyl)-4-(3-chloropropyl)piperazine dihydrochlorideHCID 20153170409.8%

Reaction Steps

The procedure described in Example 17(a) was followed, using 16.5 g of 1-(1-phenylethyl)piperazine, 8.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 9.5 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 28.0 g (96% of theory) of 1-(1-phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04722926
Source datasetuspto-grants-1988_02
ORD IDord-93cf949e00b544a7b8fbd151bc44a719
Source noteuspto-grants-1988_02