HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-[4-(1-Phenylethyl)piperazin-1-yl]propanethiol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 1-(1-Phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153170 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[4-(1-Phenylethyl)piperazin-1-yl]propanethiol dihydrochloride | HCID 13731122 | 51% |
Reaction Steps
The procedure described in Example 1(b) was followed, using 9.8 g of thiourea, 29.0 g of 1-(1-phenylethyl)-4-(3-chloropropyl)piperazine dihydrochloride, 8.3 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 6.0 g of sodium hydroxide in 40 ml of water. Work-up, as above, gave 14.5 g (51% of theory) of 3-[4-(1-phenylethyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 252°-255° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04722926 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-d017d716638549a595ea280009b45216 |
| Source note | uspto-grants-1988_02 |