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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 3815Generated: October 23, 2026

1-Bromo-3-chloropropane → 1-Phenethyl-4-(3-chloropropyl)piperazine dihydrochloride

https://huagongshe.com/en/reaction/3815

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-chloropropaneHCID 8006—
ReactantPotassium HydroxideHCID 14797—
Reactant1-PhenethylpiperazineHCID 79214—
SolventDimethyl SulfoxideHCID 679—
Product1-Phenethyl-4-(3-chloropropyl)piperazine dihydrochlorideHCID 20153179188.8%

Reaction Steps

The procedure described in Example 1(a) was followed, using 29.4 g of 1-phenethyl piperazine, 25.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 24.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 32.6 g (64% of theory) of 1-phenethyl-4-(3-chloropropyl)piperazine dihydrochloride as an off-white crystalline solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04722926
Source datasetuspto-grants-1988_02
ORD IDord-4cbd87311b894e64af3aedbc4e278737
Source noteuspto-grants-1988_02