Methyl 4-methylaminobenzoate → HCID 20640608, compound

HRID 381743

Reaction equation

HRID 381743 reaction equation
COCOC1C=C([C@@H](N2CC[C@H](OCOC)C2)CO)C=CC=1.[CH3:23][O:24][CH2:25][O:26][C:27]1[CH:28]=[C:29]([C@H:33](O)[CH2:34][N:35]2[CH2:39][CH2:38][C@H:37]([O:40][CH2:41][O:42][CH3:43])[CH2:36]2)[CH:30]=[CH:31][CH:32]=1.[CH3:45][NH:46][C:47]1[CH:56]=[CH:55][C:50]([C:51]([O:53][CH3:54])=[O:52])=[CH:49][CH:48]=1>>[CH3:23][O:24][CH2:25][O:26][C:27]1[CH:28]=[C:29]([C@H:33]([N:46]([C:47]2[CH:56]=[CH:55][C:50]([C:51]([O:53][CH3:54])=[O:52])=[CH:49][CH:48]=2)[CH3:45])[CH2:34][N:35]2[CH2:39][CH2:38][C@H:37]([O:40][CH2:41][O:42][CH3:43])[CH2:36]2)[CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 3

HCID 140375Methyl 4-methylaminobenzoateHCID 206405831-(S)-(3-methoxymethoxyphenyl)-2-(3-(S)-methoxymethoxypyrrolidin-1-yl)ethanolHCID 206405872-(R)-(3-methoxymethoxyphenyl)-2-(3-(S)-methoxymethoxypyrrolidin-1-yl)ethanol

Product 1

HCID 20640608HCID 20640608, compoundYield 60%

Procedure

This was prepared from the mixture of 2-(R)-(3-methoxymethoxyphenyl)-2-(3-(S)-methoxymethoxypyrrolidin-1-yl)ethanol and 1-(S)-(3-methoxymethoxyphenyl)-2-(3-(S)-methoxymethoxypyrrolidin-1-yl)ethanol and methyl 4-methylaminobenzoate in 60% yield according to a procedure similar to that described in Example 1 (i).

Sources & evidence

ORD record
ord-c37814fa86f242b5abee974bbd8b75ea
Source dataset
uspto-grants-2001_10
Patent number
US06307061B2

Linked notes

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