1-Iodo-4-propylbenzene → 3-(4-Propylphenyl)-furan
Reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10]N=[CH:8][CH:7]=2)=[CH:2]1.I[C:13]1[CH:18]=CC(CCC)=[CH:15][CH:14]=1.O1C=CC(B(O)O)=C1>>[CH2:13]([C:18]1[CH:10]=[CH:11][C:6]([C:3]2[CH:4]=[CH:5][O:1][CH:2]=2)=[CH:7][CH:8]=1)[CH2:14][CH3:15]Participants
4
Procedure
As described in Example 1(d) for the preparation of 4-furan-3-yl-pyridine, 1-iodo-4-propylbenzene (500 mg, 2.03 mmol) was coupled to 3-furanboronic acid to furnish in high yield 3-(4-propylphenyl)-furan as a light brown oil that was unstable and used immediately without further purification.
Workup
- customto furnish
Sources & evidence
- ORD record
- ord-a2d874379fa649b489cde686b3eef034
- Source dataset
- uspto-grants-2001_10
- Patent number
- US06306892B1
Reaction notes
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