Chlorotrimethylsilane → 4-Benzyloxybenzyl chloride

HRID 382391

Reaction equation

HRID 382391 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17][Si](C)(C)C>CS(C)=O>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][Cl:17])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 70043(4-(Benzyloxy)phenyl)methanol

Product 1

HCID 700424-Benzyloxybenzyl chloride

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A reaction and post-treatment were carried out following the conditions of Example 71 using 3 g (14 mmol) of 4-benzyloxybenzyl alcohol, 80 ml of chlorotrimethylsilane, 1.09 ml of dimethylsulfoxide, to obtain 4-benzyloxybenzyl chloride.

Workup

  1. customA reaction

Sources & evidence

ORD record
ord-5c62664dda0a49dfaeedfe28984ce662
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Linked notes

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