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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 3824Generated: October 23, 2026

1-Bromo-3-chloropropane → 1-(3-Phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride

https://huagongshe.com/en/reaction/3824

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-3-chloropropaneHCID 8006—
ReactantPotassium HydroxideHCID 14797—
Reactant1-(3-Phenylpropyl)piperazineHCID 796534—
SolventDimethyl SulfoxideHCID 679—
Product1-(3-Phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochlorideHCID 20153184219.3%

Reaction Steps

The procedure described in Example 17(a) was followed, using 36.0 g of (3-phenylpropyl)piperazine, 25.0 g of potassium hydroxide, 125 ml of dimethyl sulfoxide and 28.0 g of 1-bromo-3-chloropropane, to give 46.0 g (73% of theory) of 1-(3-phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04722926
Source datasetuspto-grants-1988_02
ORD IDord-249a67ffce174364b0ae5c54cd4ac01c
Source noteuspto-grants-1988_02