2-Fluorobenzoyl chloride → HCID 18360435, compound
Reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:22]Participants
3
Procedure
An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.25 g (5.43 mmol) of 4-amino-1-(4-methylbenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 87 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 1.15 g 4-(2-fluorobenzoylamino)-1-(4-methylbenzyl)-5-imidazolecarboxamide (yield 60%).
Workup
- customAn amidation reaction