3-Fluorobenzoyl chloride → HCID 18360473, compound
Reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23](Cl)=[O:24]>>[F:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:24]Participants
3
Procedure
An amidation reaction and post-treatment were carried out following the conditions of Example 22, using 2.00 g (8.19 mmol) of 4-amino-1-(3-phenylpropyl)-5-imidazolecarboxamide prepared in the same manner as in Example 114 and 3-fluorobenzoyl chloride instead of benzoyl chloride to obtain 2.63 g of 4-(3-fluorobenzoylamino)-1-(3-phenylpropyl)-5-imidazolecarboxamide (yield 88%).
Workup
- customAn amidation reaction
Sources & evidence
- ORD record
- ord-a4091e99b61b4a83b5e531876b172af6