Phenylmethanesulfonyl chloride → [4-Chloro-2-[[2-methyl-4-[(phenylmethyl)sulfonyl]-1-piperazinyl]methyl]phenoxy]acetic acid
Reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)(=[O:22])=[O:21])[CH2:16][CH:15]2[CH3:29])[CH:3]=1.[CH:30]1C=CC(CS(Cl)(=O)=O)=CC=1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([S:20]([CH2:23][C:24]3[CH:30]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:21])=[O:22])[CH2:16][CH:15]2[CH3:29])[CH:3]=1Participants
3
Procedure
Prepared by the method of example 30, using the product of example 53 part (b) and benzenemethanesulfonyl chloride to give the title compound.
Workup
- customPrepared by the method of example 30
Sources & evidence
- ORD record
- ord-4ce17325f6504feaab3e708fcc28b51d