(2S)-2-Ethyl-4-(phenylmethyl)-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester → (S)-2-Ethylpiperazine, N1-BOC protected
Reaction equation
[CH2:1]([C@H:3]1[CH2:8][N:7](CC2C=CC=CC=2)[CH2:6][CH2:5][N:4]1[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH3:2]>CCO.[Pd]>[CH2:1]([C@H:3]1[CH2:8][NH:7][CH2:6][CH2:5][N:4]1[C:16]([O:18][C:19]([CH3:20])([CH3:22])[CH3:21])=[O:17])[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of the product from example 69 part c) (6.09 g) and 10% Pd/C (1.14 g) in EtOH (85 mL) was hydrogenated at 3.8 bar for 16 h. The reaction mixture was filtered through Celite and the filtrate concentrated in vacuo to give the sub-title compound as an oil (3.65 g).
Workup
- filtrationThe reaction mixture was filtered through Celite
- concentrationthe filtrate concentrated in vacuo
Sources & evidence
- ORD record
- ord-5216b17b5e254935a2298eed40070471
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08524715B2
Reaction notes
Loading…