4-(4-Methylphenoxy)piperidine → 4-[2-(4-p-Tolyloxy-piperidin-1-yl)-ethanesulfonyl]-phenol

HRID 382781

Reaction equation

HRID 382781 reaction equation
Cl[CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)(=[O:6])=[O:5].[C:14]1([CH3:27])[CH:19]=[CH:18][C:17]([O:20][CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:16][CH:15]=1>>[C:14]1([CH3:27])[CH:15]=[CH:16][C:17]([O:20][CH:21]2[CH2:26][CH2:25][N:24]([CH2:2][CH2:3][S:4]([C:7]3[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=3)(=[O:6])=[O:5])[CH2:23][CH2:22]2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 38374974-(4-Methylphenoxy)piperidineHCID 98132494-(2-Chloro-ethanesulfonyl)-phenol

Product 1

HCID 98425874-[2-(4-p-Tolyloxy-piperidin-1-yl)-ethanesulfonyl]-phenolYield 59%

Procedure

The title compound was prepared from 4-(2-chloro-ethanesulfonyl)-phenol and 4-p-tolyloxy-piperidine (prepared according to J. Med. Chem., 1978, 21, 309) in 59% yield as a white solid.

Sources & evidence

ORD record
ord-58cfce06e89b482a8455df997ba41a8f
Source dataset
uspto-grants-2001_10
Patent number
US06310213B1

Linked notes

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