4-(2-Chloro-ethanesulfonyl)-phenol → (3SR,4SR)-1-[2-(4-Hydroxy-benzenesulfonyl)-ethyl]-4-(4-methyl-benzyl)-piperidin-3-ol
Reaction equation
Cl[CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)(=[O:6])=[O:5].[CH3:14][C:15]1[CH:28]=[CH:27][C:18]([CH2:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH:21]2[OH:26])=[CH:17][CH:16]=1>>[OH:13][C:10]1[CH:11]=[CH:12][C:7]([S:4]([CH2:3][CH2:2][N:23]2[CH2:24][CH2:25][CH:20]([CH2:19][C:18]3[CH:27]=[CH:28][C:15]([CH3:14])=[CH:16][CH:17]=3)[CH:21]([OH:26])[CH2:22]2)(=[O:6])=[O:5])=[CH:8][CH:9]=1Participants
3
Procedure
The title compound was prepared from 4-(2-chloro-ethanesulfonyl)-phenol and (3SR,4SR)-4-(4-methyl-benzyl)-piperidin-3-ol in 30% yield as a white solid.
Sources & evidence
- ORD record
- ord-59dd963c7d6c4a47b62d8d9b528cc49c
- Source dataset
- uspto-grants-2001_10