4-Methoxyphenylacetyl chloride → [4-chloro-2-[[(3S)-4-[(4-methoxyphenyl)acetyl]-3-methyl-1-piperazinyl]methyl]phenoxy]-acetic Acid

HRID 38297Notes

Reaction equation

HRID 38297 reaction equation
ClC1C=C[C:5]([O:6]CC(OC(C)(C)C)=O)=C(CN(C)C2CCN(S(C3C=CC=CC=3)(=O)=O)C2)C=1.[Cl:34][C:35]1[CH:45]=[CH:44][C:38]([O:39][CH2:40][C:41]([OH:43])=[O:42])=[C:37]([CH2:46][N:47]2[CH2:52][CH2:51][N:50]([C:53](=[O:62])[CH2:54][C:55]3[CH:60]=[CH:59][C:58](F)=[CH:57][CH:56]=3)[C@@H:49]([CH3:63])[CH2:48]2)[CH:36]=1.ClC1C=CC(OCC(OC(C)(C)C)=O)=C(COS(C)(=O)=O)C=1.COC1C=CC(CC(Cl)=O)=CC=1>>[Cl:34][C:35]1[CH:45]=[CH:44][C:38]([O:39][CH2:40][C:41]([OH:43])=[O:42])=[C:37]([CH2:46][N:47]2[CH2:52][CH2:51][N:50]([C:53](=[O:62])[CH2:54][C:55]3[CH:60]=[CH:59][C:58]([O:6][CH3:5])=[CH:57][CH:56]=3)[C@@H:49]([CH3:63])[CH2:48]2)[CH:36]=1

Participants

5

Reactant 4

HCID 27346884-Methoxyphenylacetyl chlorideHCID 11633473[4-chloro-2-[[(3S)-4-[(4-fluorophenyl)acetyl]-3-methyl-1-piperazinyl]methyl]phenoxy]-acetic AcidHCID 86631070[4-chloro-2-[[(methylsulfonyl)oxy]methyl]phenoxy]-acetic Acid, 1,1-dimethylethyl EsterHCID 86631075[4-chloro-2-[[methyl[1-(phenylsulfonyl)-3-pyrrolidinyl]amino]methyl]phenoxy]-acetic Acid, 1,1-dimethylethyl Ester

Product 1

HCID 11633718[4-chloro-2-[[(3S)-4-[(4-methoxyphenyl)acetyl]-3-methyl-1-piperazinyl]methyl]phenoxy]-acetic Acid

Procedure

The title compound was prepared by the methods of example 89 part (f) and example 89 part (g) using the product of example 89 part (e) and 4-methoxy-benzeneacetyl chloride.

Sources & evidence

ORD record
ord-5da2c33f89714313b2cc2cce9bc15c35
Source dataset
uspto-grants-2013_09
Patent number
US08524715B2

Reaction notes

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