methyl (2S)-2-amino-4-(methylsulfanyl)butanoate → [4-Hydroxymethyl-2-phenylbenzoyl]methionine methyl ester
Reaction equation
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[C:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:4]=1.[CH3:18][O:19][C:20](=[O:27])[C@H:21]([CH2:23][CH2:24][S:25][CH3:26])[NH2:22]>>[CH3:18][O:19][C:20](=[O:27])[C@H:21]([CH2:23][CH2:24][S:25][CH3:26])[NH:22][C:7](=[O:9])[C:6]1[CH:10]=[CH:11][C:3]([CH2:2][OH:1])=[CH:4][C:5]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1Participants
3
Procedure
The resultant product from Example 16C is coupled to methionine methyl ester according to the procedure of Example 1C to give the title compound.
Sources & evidence
- ORD record
- ord-80ed17082deb417292e9efbbc5ab1c85
- Source dataset
- uspto-grants-2001_10
- Patent number
- US06310095B1