1-Isocyanato-4-methoxybenzene → HCID 178418524, compound
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]=[O:11])=[CH:5][CH:4]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][CH2:30][SH:31])[CH2:24][CH2:23]2)=[CH:15][CH:14]=1>C=Cl>[OH2:2].[ClH:12].[ClH:12].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[SH:31][CH2:30][CH2:29][CH2:28][N:25]2[CH2:26][CH2:27][N:22]([CH2:21][CH2:20][CH2:19][C:16]3[CH:17]=[CH:18][C:13]([Cl:12])=[CH:14][CH:15]=3)[CH2:23][CH2:24]2)[OH:11])=[CH:7][CH:8]=1.[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[SH:31][CH2:30][CH2:29][CH2:28][N:25]2[CH2:26][CH2:27][N:22]([CH2:21][CH2:20][CH2:19][C:16]3[CH:17]=[CH:18][C:13]([Cl:12])=[CH:14][CH:15]=3)[CH2:23][CH2:24]2)[OH:11])=[CH:7][CH:8]=1.[ClH:12].[ClH:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The procedure described in Example 35 was followed, using 2.0 g of 4-methoxyphenyl isocyanate, 4.0 g of 3-{4-[3-(4-chlorophenyl)propyl]piperazin-1-yl}propanethiol and 100 ml of methylene chlorine to give 3.4 g (48% of theory) of N-(4-methoxyphenyl)-S-{3-[4-[3-(4-chlorophenyl)propyl]piperazin-1-yl]propyl}thiocarbamate dihydrochloride hemihydrate as a white crystalline solid, M.p. 240°-244° C.