3-Furanol, tetrahydro- → 3-Bromo-2-methyl-6-((tetrahydrofuran-3-yl)oxy)pyridine

Reaction equation

[Br:1][C:2]1[C:3]([CH3:9])=[N:4][C:5]([OH:8])=[CH:6][CH:7]=1.O[CH:11]1[CH2:15][CH2:14][O:13][CH2:12]1>>[Br:1][C:2]1[C:3]([CH3:9])=[N:4][C:5]([O:8][CH:11]2[CH2:15][CH2:14][O:13][CH2:12]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 99603-Furanol, tetrahydro-

HCID 178433439HCID 178433439, compound

Product 1

HCID 684093293-Bromo-2-methyl-6-((tetrahydrofuran-3-yl)oxy)pyridine

Procedure

The title compound was prepared from 3-bromo-6-hydroxy-2-methylpyridine and rac-3-hydroxy-tetrahydrofuran in analogy to Example 9c): colorless solid.

Sources & evidence

ORD record: ord-ff3e0153766c46bebe51e84e28e1cbff
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367838B2

Reaction notes

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