3-Isopropoxybenzeneboronic acid → Rac-[1-(3,4-dichloro-phenyl)-2-(3'-isopropoxy-biphenyl-4-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384969

Reaction equation

HRID 384969 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14](I)=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[CH:27]([O:30][C:31]1[CH:32]=[C:33](B(O)O)[CH:34]=[CH:35][CH:36]=1)([CH3:29])[CH3:28]>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([C:35]2[CH:34]=[CH:33][CH:32]=[C:31]([O:30][CH:27]([CH3:29])[CH3:28])[CH:36]=2)=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 50839323-Isopropoxybenzeneboronic acidHCID 68409915Rac-[1-(3,4-dichloro-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 68408675Rac-[1-(3,4-dichloro-phenyl)-2-(3'-isopropoxy-biphenyl-4-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from rac-[1-(3,4-dichloro-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 3-isopropoxyphenylboronic acid in analogy to Example 2b): MS (ISN): 512.3 and 514.3 (M−H)−.

Sources & evidence

ORD record
ord-fc555b2ce66d455582447e23789f4dd5
Source dataset
uspto-grants-2013_02
Patent number
US08367838B2

Linked notes

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