3-Chloro-4-fluoroaniline → N-(3-Chloro-4-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-d]azepin-4-amine

Participants

Reaction Steps

The title compound was prepared in analogy to Example 12A from tert-butyl 4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[5′,4′:4,5]thieno[2,3-d]azepine-7-carboxylate from Example 84A (680 mg, 2.00 mmol) and 3-chloro-4-fluoroaniline (306 mg, 2.10 mmol) to yield 419 mg (60%).

Provenance & Evidence