1-Oxa-3,8-diazaspiro(4.5)decan 2-one → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 385782

Reaction equation

HRID 385782 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[C:12]1[S:16][C:15]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]=O)[N:19]=2)=[C:14]([C:26]([NH2:28])=[O:27])[CH:13]=1.[O:29]1[C:33]2([CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH2:32][NH:31][C:30]1=[O:39]>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:11])([CH3:9])[CH3:10])[CH:5]=[CH:4][C:3]=1[C:12]1[S:16][C:15]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][N:36]3[CH2:35][CH2:34][C:33]4([O:29][C:30](=[O:39])[NH:31][CH2:32]4)[CH2:38][CH2:37]3)[N:19]=2)=[C:14]([C:26]([NH2:28])=[O:27])[CH:13]=1

Participants

3

Reactant 2

HCID 129541141-Oxa-3,8-diazaspiro(4.5)decan 2-oneHCID 59526158HCID 59526158, compound

Product 1

HCID 595255945-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

Procedure

The title compound was prepared according to Example 106 Step 2 using 5-(2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamide (19.5 mg, 0.05 mmol) and 1-oxa-3,8-diaza-spiro[4.5]decan-2-one (7.6 mg, 0.05 mmol) as the starting materials.

Sources & evidence

ORD record
ord-eac57c445eae4eb0aa53c3d2540b568c
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Linked notes

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