2-Bromo-6-methylpyridine → 2-(6-Bromopyridin-2-yl)-1-(tetrahydro-2H-thiopyran-4-yl)ethanol

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N:3]=1.[S:9]1[CH2:14][CH2:13][CH:12]([CH:15]=[O:16])[CH2:11][CH2:10]1>>[Br:1][C:2]1[N:3]=[C:4]([CH2:8][CH:15]([CH:12]2[CH2:13][CH2:14][S:9][CH2:10][CH2:11]2)[OH:16])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 792052-Bromo-6-methylpyridine

HCID 20143720Thiane-4-carbaldehyde

Product 1

HCID 595260312-(6-Bromopyridin-2-yl)-1-(tetrahydro-2H-thiopyran-4-yl)ethanol

Procedure

The title compound was prepared according to the procedure in Example 158 Step 1 using 2-bromo-6-methylpyridine (1.5 g, 8.72 mmol) and tetrahydro-2H-thiopyran-4-carbaldehyde (2.27 g, 17.4 mmol) as the starting materials.

Sources & evidence

ORD record: ord-74980b4caa884b1b9a7378aade85df60
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367706B2

Reaction notes

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