(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → N-[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]-6-[(2E)-4-(dimethylamino)but-2-enoyl]-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

Participants

Reaction Steps

In analogy to Example 89, the title compound was prepared from N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-6,7-dihydro-5H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 31A (38 mg, 0.094 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (22 mg, 0.13 mmol) to yield 18 mg (37%).

Provenance & Evidence