2-[(6-Bromopyridin-2-yl)oxy]ethanol → HCID 59525738, compound
Reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:22]1[N:27]=[C:26]([O:28][CH2:29][CH2:30][OH:31])[CH:25]=[CH:24][CH:23]=1>>[F:20][C:11]1[CH:12]=[C:13]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:4]1[S:3][C:2]([NH:1][C:22]2[CH:23]=[CH:24][CH:25]=[C:26]([O:28][CH2:29][CH2:30][OH:31])[N:27]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1Participants
3
Procedure
The title compound was prepared as described in Example 205, Step 2 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (60 mg, 0.20 mmol) and 2-[(6-bromopyridin-2-yl)oxy]ethanol (48.8 mg, 0.22 mmol) as starting materials.
Sources & evidence
- ORD record
- ord-e2c7b234834c4bbaa98061eda4808786
- Source dataset
- uspto-grants-2013_02