Potassium Hydroxide → 8-(5-Bromo-2,4-dimethoxy-phenyl)-purin-6-one

HRID 3859

Reaction equation

HRID 3859 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[NH:4][C:5]([C:11]1[CH:16]=[C:15]([Br:17])[C:14]([O:18][CH3:19])=[CH:13][C:12]=1[O:20][CH3:21])=[N:6]2.[OH-:22].[K+]>>[Br:17][C:15]1[C:14]([O:18][CH3:19])=[CH:13][C:12]([O:20][CH3:21])=[C:11]([C:5]2[N:4]=[C:3]3[C:7](=[N:8][CH:9]=[N:10][C:2]3=[O:22])[N:6]=2)[CH:16]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 201532746-Chloro-8-(2,4-dimethoxy-5-bromo-phenyl)-purine

Product 1

HCID 201532048-(5-Bromo-2,4-dimethoxy-phenyl)-purin-6-one

Procedure

Prepared analogously to Example 16 from 6-chloro-8-(5-bromo-2,4-dimethoxy-phenyl)-purine by reaction with 20% potassium hydroxide solution.

Sources & evidence

ORD record
ord-2a4c687c874b41f689e1af3834786261
Source dataset
uspto-grants-1988_02
Patent number
US04722929

Linked notes

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