2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[6-(1-Cyanocyclopropyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 385911

Reaction equation

HRID 385911 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.[NH2:13][C:14]1[S:15][C:16]([C:22]2[C:27]([F:28])=[CH:26][C:25]([C:29]([OH:32])([CH3:31])[CH3:30])=[CH:24][C:23]=2[F:33])=[CH:17][C:18]=1[C:19]([NH2:21])=[O:20]>>[C:11]([C:8]1([C:6]2[N:7]=[C:2]([NH:13][C:14]3[S:15][C:16]([C:22]4[C:23]([F:33])=[CH:24][C:25]([C:29]([OH:32])([CH3:30])[CH3:31])=[CH:26][C:27]=4[F:28])=[CH:17][C:18]=3[C:19]([NH2:21])=[O:20])[CH:3]=[CH:4][CH:5]=2)[CH2:10][CH2:9]1)#[N:12]

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595256751-(6-Bromopyridin-2-YL)cyclopropanecarbonitrile

Product 1

HCID 595255722-{[6-(1-Cyanocyclopropyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Procedure

The title compound was prepared according to the procedure described in Example 1 using 1-(6-bromopyridin-2-yl)cyclopropanecarbonitrile (107 mg, 0.48 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) as starting materials.

Sources & evidence

ORD record
ord-ab4cfb6f6dd84022ae903b9934098b2c
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Linked notes

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