2-Bromo-6-(methylsulfonyl)pyridine → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(methylsulfonyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([S:28]([CH3:31])(=[O:30])=[O:29])[N:23]=1>>[F:20][C:11]1[CH:12]=[C:13]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:4]1[S:3][C:2]([NH:1][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([S:28]([CH3:31])(=[O:30])=[O:29])[N:23]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1Participants
3
Procedure
The title compound was prepared using the procedure described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.13 g, 0.44 mmol) and 2-bromo-6-(methylsulfonyl)pyridine (0.10 g, 0.44 mmol) as the starting materials.
Sources & evidence
- ORD record
- ord-6d077139c7d642edb336bc3fa831a43f