HCID 15325851, compound → HCID 59526277, compound
Reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[N:28]=[C:27]([C:29]2[CH:34]=[CH:33][C:32](=[O:35])[N:31]([CH3:36])[CH:30]=2)[CH:26]=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[N:28]=[C:27]([C:29]3[CH:34]=[CH:33][C:32](=[O:35])[N:31]([CH3:36])[CH:30]=3)[CH:26]=[CH:25][CH:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1Participants
3
Procedure
The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (38 mg, 0.12 mmol) and 6-bromo-1′-methyl-2,3′-bipyridin-6′(1′H)-one (33 mg, 0.12 mmol) as starting materials.
Sources & evidence
- ORD record
- ord-14a8b5c266eb455ebde91eb16df8eca6
- Source dataset
- uspto-grants-2013_02