4-Bromocrotonic acid → HCID 58116851, compound

Participants

Reaction Steps

The title compound was synthesized in analogy to Example 130 from N-[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 62A (100 mg, 0.24 mmol), (2E)-4-bromobut-2-enoic acid (75 mg, 0.36 mmol) and 1,4-oxazepane hydrochloride (53 mg, 0.39 mmol) to yield 62 mg (42%).

Provenance & Evidence