(2-Methoxyethyl)(methyl)amine → 3-Chloro-5-[(7-{(2E)-4-[(2-methoxyethyl)(methyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)amino]phenol

Participants

Reaction Steps

In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (84 mg, 0.41 mmol), 3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 65A (100 mg, 0.27 mmol) and 2-methoxy-N-methylethanamine (39 mg, 0.43 mmol) to yield 24 mg (18%).

Provenance & Evidence