2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → Methyl 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-5-carboxylate

HRID 386048Notes

Reaction equation

HRID 386048 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][N:9]2[C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][N:11]=[N:10]2)[CH:5]=[CH:4][CH:3]=1.[NH2:18][C:19]1[S:20][C:21]([C:27]2[C:32]([F:33])=[CH:31][C:30]([C:34]([OH:37])([CH3:36])[CH3:35])=[CH:29][C:28]=2[F:38])=[CH:22][C:23]=1[C:24]([NH2:26])=[O:25]>>[NH2:26][C:24]([C:23]1[CH:22]=[C:21]([C:27]2[C:32]([F:33])=[CH:31][C:30]([C:34]([OH:37])([CH3:36])[CH3:35])=[CH:29][C:28]=2[F:38])[S:20][C:19]=1[NH:18][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][N:11]=[N:10]2)[CH:5]=[CH:4][CH:3]=1)=[O:25]

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525904Methyl 1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazole-5-carboxylate

Product 1

HCID 59526199Methyl 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-5-carboxylate

Procedure

The title compound was synthesized from methyl 1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazole-5-carboxylate (166 mg, 0.56 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (175 mg, 0.56 mmol) according to the general procedure in Example 1.

Sources & evidence

ORD record
ord-0fa2bef3b19c46d0b187c2471289570d
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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