4-Bromocrotonic acid → HCID 58116817, compound

Participants

Reaction Steps

In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (84 mg, 0.41 mmol), 3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 65A (100 mg, 0.27 mmol) and 1,4-oxazepane hydrochloride (60 mg, 0.43 mmol) to yield 30 mg (22%).

Provenance & Evidence