4-Hydroxypyrrolidine → 1-(4-Ethoxypyrimidin-2-yl)pyrrolidin-3-ol

Reaction equation

Cl[C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12]1>>[CH2:9]([O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:11]2[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12]2)[N:7]=1)[CH3:10]

Participants

Reactant 2

HCID 982104-Hydroxypyrrolidine

HCID 47372802-Chloro-4-ethoxypyrimidine

Product 1

HCID 595262421-(4-Ethoxypyrimidin-2-yl)pyrrolidin-3-ol

Procedure

The title compound was prepared as described in Example 555, Step 2 using 2-chloro-4-ethoxypyrimidine (2.4 g, 15 mol) and pyrrolidin-3-ol (1.6 g, 18 mmol) as the starting materials.

Sources & evidence

ORD record: ord-22a0f1e4b62d4514b25f48f32606bca5
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08367706B2

Reaction notes

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