2-(2-Morpholinyl)ethanol → HCID 59526309, compound
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=O)[N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH:12]([CH2:16][CH2:17][OH:18])[CH2:11]1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][N:10]2[CH2:15][CH2:14][O:13][CH:12]([CH2:16][CH2:17][OH:18])[CH2:11]2)[N:3]=1Participants
3
Procedure
The title compound was prepared as described in Example 106, Step 1 with 4-chloropyrimidine-2-carbaldehyde (110 mg, 0.84 mmol) and 2-morpholin-2-ylethanol (100 mg, 0.70 mmol) as starting materials.
Sources & evidence
- ORD record
- ord-b0540f05804f4f03a151eff490afc582
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08367706B2
Reaction notes
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